Predicting the System Performance by Combining Calibrated Performance Models of its Components : A Preliminary Study

International audienceIn this paper we consider the problem of combining calibrated performance models of system components in order to predict overall system performance. We focus on open workload system models, in which, under certain conditions, obtaining and validating the overall system performance measures can be a simple application of Little’s law. We discuss the conditions of applicability of such a simple validation methodology, including examples of successful application, as well as examples where this approach fails.Additionally, we propose to analyze the deviations between the model predictions and system measurements, so as to decide if they correspond to “measurement noise” or if an important system component has not been correctly represented. This approach can be used as an aid in the design of validated system performance models

Efficient operation of a high-power X-band gyroklystron

Experimental studies of amplification in a two-cavity X-band gyroklystron are reported. The system utilizes a thermionic magnetron injection gun at voltages up to 440 kV and currents up to 190 A in 1-μs pulses. Optimum performance is achieved by tapering the magnetic-field profile. Peak powers of 20 MW in the TE01 mode at 9.87 GHz are measured with calibrated crystals and with methanol calorimetry. Resultant efficiencies are in excess of 31% and large-signal gains surpass 26 dB. The experimental results are in good agreement with simulated results from a partially self-consistent, nonlinear, steady-state code

FOREVER: Fault/intrusiOn REmoVal through Evolution & Recovery

The goal of the FOREVER project is to develop a service for Fault/intrusiOn REmoVal through Evolution & Recovery. In order to achieve this goal, our work addresses three main tasks: the definition of the FOREVER service architecture; the analysis of how diversity techniques can improve resilience; and the evaluation of the FOREVER service. The FOREVER service is an important contribution to intrustion-tolerant replication middleware and significantly enhances the resilience

High-power operation of a K-band second harmonic gyroklystron

Amplification studies of a two-cavity second-harmonic gyroklystron are reported. A magnetron injection gun produces a 440 kV, 200–245 A, 1 μs beam with an average perpendicular-to-parallel velocity ratio slightly less than 1. The TE011 input cavity is driven near 9.88 GHz and the TE021 output cavity resonates near 19.76 GHz. Peak powers exceeding 21 MW are achieved with an efficiency near 21% and a large signal gain above 25 dB. This performance represents the current state of the art for gyroklystrons in terms of the peak power normalized to the output wavelength squared

Ibuprofen Ameliorates Fatigue- And Depressive-Like Behavior in Tumor-Bearing Mice

Aims: Cancer-related fatigue (CRF) is often accompanied by depressed mood, both of which reduce functional status and quality of life. Research suggests that increased expression of pro-inflammatory cytokines is associated with skeletal muscle wasting and depressive- and fatigue-like behaviors in rodents and cancer patients. We have previously shown that treatment with ibuprofen, a nonsteroidal anti-inflammatory drug, preserved muscle mass in tumor-bearing mice. Therefore, the purpose of the present study was to determine the behavioral effects of ibuprofen in a mouse model of CRF. Main methods: Mice were injected with colon-26 adenocarcinoma cells and treated with ibuprofen (10 mg/kg) in the drinking water. Depressive-like behavior was determined using the forced swim test (FST). Fatigue-like behaviors were determined using voluntary wheel running activity (VWRA) and grip strength. The hippocampus, gastrocnemius muscle, and serum were collected for cytokine analysis. Key findings: Tumor-bearing mice showed depressive-like behavior in the FST, which was not observed in mice treated with ibuprofen. VWRA and grip strength declined in tumor-bearing mice, and ibuprofen attenuated this decline. Tumor-bearing mice had decreased gastrocnemius muscle mass and increased expression of IL-6, MAFBx and MuRF mRNA, biomarkers of protein degradation, in the muscle. Expression of IL-1β and IL-6 was also increased in the hippocampus. Treatment with ibuprofen improved muscle mass and reduced cytokine expression in both the muscle and hippocampus of tumor-bearing mice. Significance: Ibuprofen treatment reduced skeletal muscle wasting, inflammation in the brain, and fatigue- and depressive-like behavior in tumor-bearing mice. Therefore, ibuprofen warrants evaluation as an adjuvant treatment for CRF

Women in radiology: gender diversity is not a metric-it is a tool for excellence.

Women in Focus: Be Inspired was a unique programme held at the 2019 European Congress of Radiology that was structured to address a range of topics related to gender and healthcare, including leadership, mentoring and the generational progression of women in medicine. In most countries, women constitute substantially fewer than half of radiologists in academia or private practice despite frequently accounting for at least half of medical school enrolees. Furthermore, the proportion of women decreases at higher academic ranks and levels of leadership, a phenomenon which has been referred to as a "leaky pipeline". Gender diversity in the radiologic workplace, including in academic and leadership positions, is important for the present and future success of the field. It is a tool for excellence that helps to optimize patient care and research; moreover, it is essential to overcome the current shortage of radiologists. This article reviews the current state of gender diversity in academic and leadership positions in radiology internationally and explores a wide range of potential reasons for gender disparities, including the lack of role models and mentorship, unconscious bias and generational changes in attitudes about the desirability of leadership positions. Strategies for both individuals and institutions to proactively increase the representation of women in academic and leadership positions are suggested. KEY POINTS: • Gender-diverse teams perform better. Thus, gender diversity throughout the radiologic workplace, including in leadership positions, is important for the current and future success of the field. • Though women now make up roughly half of medical students, they remain underrepresented among radiology trainees, faculty and leaders. • Factors leading to the gender gap in academia and leadership positions in Radiology include a lack of role models and mentors, unconscious biases, other societal barriers and generational changes